Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.43 |
| ▸ | MAOB | P27338 | 8/20 | 0.43 |
| ▸ | ALPL | P05186 | 3/20 | 0.35 |
| ▸ | ALPI | P09923 | 3/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11170592 | 0.83 | MAOB (0.43) | MAOAMAOBALPLALPICCR4 | |
| Bromide SCHEMBL11173907 | 0.79 | MAOB (0.43) | MAOAMAOBCCR4NPC1RAB9A | |
| Bromide SCHEMBL11167726 | 0.78 | KDM4E (0.39) | MAOAMAOBKDM4EALDH1A1GAA | |
| Bromide SCHEMBL11173956 | 0.66 | MAOB (0.39) | MAOAMAOBNPC1RAB9AAHR | |
| Bromide SCHEMBL11238851 | 0.64 | GNAI3 (0.35) | GAAKMT2A | |
| Bromide SCHEMBL11176112 | 0.64 | MAOB (0.35) | MAOAMAOBALPLALPINPC1 | |
| SCHEMBL10648746 | 0.62 | HSD17B3 (0.55) | MAOAMAOBKDM4EALDH1A1GAA | |
| Bromide SCHEMBL11181035 | 0.61 | MAOB (0.35) | MAOAMAOBAHRKMT2A | |
| Bromide SCHEMBL11089523 | 0.60 | MAOB (0.46) | MAOB | |
| SCHEMBL21655151 | 0.59 | MAOB (0.41) | MAOAMAOBCCR4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4376776-A | Dibenzofuran derivatives and their use for controlling fungi | BASF AKTIENGESELLSCHAFT (DE) | 1983-03-15 | — | — | US | disclosed |