Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.71 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 3/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808443 | 0.89 | MTOR (0.82) | MTORNAMPTCA9CA12CA1 | |
| SCHEMBL11614619 | 0.87 | MMP13 (0.58) | MTORROCK2ROCK1NAMPTCA9 | |
| SCHEMBL11615792 | 0.87 | TSHR (0.63) | MTORROCK2ROCK1NAMPTNPY5R | |
| SCHEMBL11615157 | 0.85 | MTOR (0.54) | MTORROCK2ROCK1NAMPTCA9 | |
| SCHEMBL11612243 | 0.85 | MTOR (0.54) | MTORROCK2ROCK1NAMPTALDH1A1 | |
| SCHEMBL11613400 | 0.85 | MTOR (0.54) | MTORROCK2ROCK1NAMPTALDH1A1 | |
| SCHEMBL11615678 | 0.84 | MTOR (0.53) | MTORROCK2ROCK1NAMPTALDH1A1 | |
| SCHEMBL11616832 | 0.84 | CA12 (0.52) | MTORROCK2ROCK1NAMPTCA9 | |
| SCHEMBL29140936 | 0.83 | MTOR (0.78) | MTORNAMPTCA9CA12CA1 | |
| SCHEMBL11614065 | 0.83 | LMNA (0.54) | MTORROCK2ROCK1NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4370328-A | Cardiac stimulant 1-(3- or 4-substituted piperidino)phthalazines | PFIZER INC. (US) | 1983-01-25 | — | — | US | disclosed |
| EP-0017411-B1 | PHTHALAZINE CARDIAC STIMULANTS, PROCESSES FOR PREPARING THEM, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pfizer Limited (GB) | 1982-03-31 | — | — | EP | disclosed |
| EP-0017411-A1 | Phthalazine cardiac stimulants, processes for preparing them, and pharmaceutical compositions containing them | Pfizer Limited (GB) | 1980-10-15 | — | — | EP | disclosed |