Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | DRD1 | P21728 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169289 | 0.87 | CYP3A4 (0.38) | KDM4ENPY1RNPY2RSMN1; SMN2DRD1 | |
| Fumaric Acid SCHEMBL11169435 | 0.78 | SMN1; SMN2 (0.41) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| Fumaric Acid SCHEMBL11169441 | 0.78 | SMN1; SMN2 (0.41) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| SCHEMBL10700513 | 0.75 | CYP3A4 (0.47) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| SCHEMBL10702749 | 0.74 | DRD1 (0.41) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| SCHEMBL11171000 | 0.73 | DRD1 (0.38) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| SCHEMBL11171087 | 0.69 | TDP1 (0.35) | SMN1; SMN2DRD2DRD1TDP1L3MBTL1 | |
| SCHEMBL7329836 | 0.68 | DRD1 (0.60) | KDM4EDRD2DRD1CYP3A4CYP2D6 | |
| SCHEMBL11155684 | 0.67 | DRD2 (0.41) | KDM4ENPY1RNPY2RSMN1; SMN2DRD2 | |
| Hydrochloric Acid SCHEMBL7328826 | 0.67 | DRD1 (0.59) | KDM4EDRD2DRD1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |