Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 6/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.72 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.72 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.72 |
| ▸ | HTR1D | P28221 | 1/20 | 0.65 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.56 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741885 | 0.84 | ADRA2A (0.77) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11098850 | 0.84 | ADRA2A (0.69) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL8020019 | 0.84 | ADRA2A (1.00) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL29412295 | 0.82 | ADRA2A (0.65) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL4760243 | 0.79 | HTR1D (1.00) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11176814 | 0.79 | ADRA2A (0.79) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11169014 | 0.79 | ADRA1A (0.77) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| Hydrochloric Acid SCHEMBL29384552 | 0.78 | HTR1D (0.97) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11859273 | 0.78 | ADRA2A (0.68) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL11757404 | 0.76 | ADRA2A (0.63) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4389403-A | HYPOTENSIVE AGENTS | BASF AKTIENGESELLSCHAFT (DE) | 1983-06-21 | — | — | US | disclosed |
| EP-0037471-A1 | 1-Aroyl-2-phenylamino-2-imidazolines, their preparation and their pharmaceutical compositions | BASF Aktiengesellschaft (DE) | 1981-10-14 | — | — | EP | disclosed |
| US-4094964-A | IMMUNOASSAY, HAPTEN, ANTIGEN | HOFFMANN-LA ROCHE INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4025607-A | ANALGESICS, HYPOTENSIVES | BOEHRINGER INGELHEIM GMBH (DT) | 1977-05-24 | — | — | US | disclosed |
| US-3950523-A | ANTIDEPRESSANTS | BOEHRINGER INGELHEIM GMBH (DT) | 1976-04-13 | — | — | US | disclosed |