Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 14/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42581 | 0.79 | OPRL1 (0.52) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL28218849 | 0.76 | OPRM1 (0.42) | OPRL1OPRM1OPRK1CYP2D6CYP2C9 | |
| SCHEMBL4277748 | 0.76 | OPRL1 (0.44) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL7815717 | 0.71 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL10060840 | 0.71 | OPRL1 (0.68) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL20271883 | 0.68 | OPRL1 (0.36) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL1724862 | 0.68 | OPRL1 (0.57) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL1109741 | 0.68 | OPRL1 (0.57) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL19458977 | 0.68 | OPRL1 (0.47) | OPRL1OPRM1OPRK1OPRD1POLB | |
| SCHEMBL28524217 | 0.68 | OPRL1 (0.47) | OPRL1OPRM1OPRK1OPRD1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027928-B1 | PIPERIDINE DERIVATIVES OF 4,5-DIALKYL-3-HYDROXY-PYRROLE-2-CARBOXYLIC ACID ESTERS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1983-03-09 | — | — | EP | disclosed |
| EP-0027928-A2 | Piperidine derivatives of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters, their preparation and pharmaceutical compositions containing them | BASF Aktiengesellschaft (DE) | 1981-05-06 | — | — | EP | disclosed |