Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11184581 | 0.87 | POLB (0.40) | ALDH1A1MAPTPOLB | |
| SCHEMBL11263001 | 0.81 | POLB (0.40) | ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL11199916 | 0.80 | SMN1; SMN2 (0.44) | ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL11202283 | 0.79 | POLB (0.38) | ALDH1A1KDM4EMAPTPOLB | |
| SCHEMBL11183987 | 0.79 | GAA (0.57) | ALDH1A1POLB | |
| SCHEMBL9250009 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTPOLBNPSR1 | |
| SCHEMBL9250005 | 0.78 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPTPOLBNPSR1 | |
| SCHEMBL11190505 | 0.78 | HTT (0.39) | ALDH1A1 | |
| SCHEMBL11194045 | 0.78 | ACE (0.51) | ALDH1A1POLB | |
| SCHEMBL11186430 | 0.77 | ALDH1A1 (0.44) | ALDH1A1KDM4EPOLBBLMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |