Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11183987 | 0.88 | GAA (0.57) | POLBGAARAB9AMEN1KMT2A | |
| SCHEMBL11202283 | 0.88 | POLB (0.38) | POLBGAARAB9AKDM4EMAPT | |
| SCHEMBL11184581 | 0.87 | POLB (0.40) | POLBGAARAB9AMAPTHSD17B10 | |
| SCHEMBL11189268 | 0.81 | ALDH1A1 (0.44) | POLBKDM4EMAPTALDH1A1 | |
| SCHEMBL11201178 | 0.81 | GAA (0.42) | POLBGAARAB9AKDM4EFFAR2 | |
| SCHEMBL11194045 | 0.80 | ACE (0.51) | POLBKMT2AFFAR2ALDH1A1HPGD | |
| SCHEMBL11199610 | 0.79 | TUBB4A (0.38) | POLBGAARAB9AMAPTKMT2A | |
| SCHEMBL11190617 | 0.79 | FFAR2 (0.44) | POLBGAARAB9AKDM4EMAPT | |
| SCHEMBL11199916 | 0.78 | SMN1; SMN2 (0.44) | POLBGAARAB9AKDM4EMAPT | |
| SCHEMBL11219804 | 0.76 | ACE (0.36) | POLBMEN1KMT2AFFAR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |