Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11219804 | 0.85 | ACE (0.36) | ACEALDH1A1POLBHPGDLMNA | |
| SCHEMBL11194340 | 0.80 | TERT (0.38) | ACEFFAR2 | |
| SCHEMBL11263001 | 0.80 | POLB (0.40) | ACEALDH1A1POLBHPGDFFAR2 | |
| SCHEMBL11190617 | 0.79 | FFAR2 (0.44) | ACEALDH1A1POLBHPGDLMNA | |
| SCHEMBL11184581 | 0.79 | POLB (0.40) | ALDH1A1POLBHPGDFFAR2KMT2A | |
| SCHEMBL10969787 | 0.78 | ACE (0.57) | ACEALDH1A1POLBHPGDLMNA | |
| SCHEMBL11189268 | 0.78 | ALDH1A1 (0.44) | ALDH1A1POLB | |
| SCHEMBL11192054 | 0.77 | ACE (0.36) | ACEALDH1A1 | |
| SCHEMBL11201178 | 0.77 | GAA (0.42) | POLBFFAR2 | |
| SCHEMBL11202283 | 0.77 | POLB (0.38) | ALDH1A1POLBHPGDFFAR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | claimed |
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |