Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 3/20 | 0.30 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | F10 | P00742 | 1/20 | 0.30 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962806 | 0.89 | GSK3B (0.38) | GSK3BBTKJAK3DPP4CNR1 | |
| SCHEMBL8003442 | 0.81 | GSK3B (0.37) | GSK3BBTKJAK3CCR4DPP4 | |
| SCHEMBL1962175 | 0.81 | GSK3B (0.35) | GSK3BBTKJAK3DPP4IL1B | |
| SCHEMBL1119579 | 0.80 | BMPR1B (0.32) | BTKJAK3DPP4EGFRLCK | |
| SCHEMBL1120117 | 0.76 | MAPK14 (0.32) | GSK3BBTKJAK3IL1BEGFR | |
| SCHEMBL1120237 | 0.72 | GSK3B (0.34) | GSK3B | |
| SCHEMBL1962515 | 0.72 | DPP4 (0.34) | GSK3BDPP4 | |
| SCHEMBL8006538 | 0.71 | GSK3B (0.34) | GSK3BDPP4HTTSMN1; SMN2 | |
| SCHEMBL16456992 | 0.71 | WNT1 (0.31) | BTKJAK3IL1BEGFRLCK | |
| SCHEMBL1120012 | 0.70 | LMNA (0.36) | DPP4CNR1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280976-A1 | SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AS GSK3BETA-INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009138176-A1 | SUBSTITUTED IMIDAZO- AND TRIAZOLOPYRIMIDINES, IMIDAZO- AND PYRAZOLOPYRAZINES AND IMIDAZOTRIAZINES AS GSK3BETA-INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-11-19 | — | — | WO | disclosed |