Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664870 | 0.84 | THRB (0.62) | ELANETHRBTHRAPTGS2S1PR1 | |
| SCHEMBL11194767 | 0.82 | ELANE (0.50) | ELANETHRBTHRAPTGS2ALOX15 | |
| SCHEMBL7283291 | 0.80 | ELANE (0.54) | ELANETHRBTHRAPTGS2ALOX15 | |
| SCHEMBL3247915 | 0.80 | THRB (0.49) | ELANETHRBTHRAPTGS2 | |
| SCHEMBL11197886 | 0.80 | THRB (0.48) | ELANETHRBTHRAPTGS2ALOX15 | |
| SCHEMBL11193665 | 0.79 | ALDH1A3 (0.47) | THRBS1PR1S1PR4S1PR5S1PR2 | |
| SCHEMBL28707103 | 0.77 | PTGS2 (0.64) | ELANETHRBPTGS2ALOX15ADRB2 | |
| SCHEMBL27241091 | 0.77 | CALM1 (0.53) | ALOX15 | |
| SCHEMBL11044754 | 0.77 | CALM1 (0.53) | ALOX15 | |
| SCHEMBL20179174 | 0.76 | ELANE (0.45) | ELANETHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415572-A | CARDIOTONIC AND INOTROPIC AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1983-11-15 | — | — | US | disclosed |