Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 6/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2241711 | 0.80 | MIF (0.42) | MIF | |
| SCHEMBL602013 | 0.79 | NAAA (0.40) | NAAAHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL25268577 | 0.79 | NAAA (0.46) | NAAATUBB1HTR3EHTR3BHTR3A | |
| SCHEMBL457065 | 0.77 | ACHE (0.46) | TUBB1 | |
| SCHEMBL12762508 | 0.76 | TUBB1 (0.37) | TUBB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL23760097 | 0.76 | GAA (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL10086105 | 0.72 | TUBB1 (0.42) | TUBB1KDM1A | |
| SCHEMBL76835 | 0.72 | HTR3E (0.53) | TUBB1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6179404 | 0.69 | P2RY6 (0.38) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11551368 | 0.69 | NAAA (0.38) | NAAATUBB1APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280945-B1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-03 | — | — | EP | disclosed |
| US-8779158-B2 | Trisubstituted pyrazoles as acetylcholine receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-15 | — | — | US | disclosed |
| US-8779158-B2 | Trisubstituted pyrazoles as acetylcholine receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-15 | — | — | US | disclosed |
| US-8779158-B2 | Trisubstituted pyrazoles as acetylcholine receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-15 | — | — | US | disclosed |
| US-20110065683-A1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-17 | — | — | US | disclosed |
| EP-2280945-A1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009135944-A1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009135944-A1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065683-A1 | TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA1, CHRM3, CHRNA5 | NAAA 1272/4885TUBB1 2142/4885HTR3E 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.