Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242212 | 0.94 | KEAP1 (0.53) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL11741034 | 0.88 | KEAP1 (0.59) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13089543 | 0.87 | HDAC1 (0.60) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13443080 | 0.87 | MAPT (0.61) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL19561359 | 0.86 | HDAC1 (0.69) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL497371 | 0.85 | KEAP1 (0.73) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL19625551 | 0.84 | MAPT (0.68) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL107423 | 0.83 | KEAP1 (0.70) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL712597 | 0.83 | KEAP1 (0.70) | KEAP1HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3893395 | 0.82 | L3MBTL1 (0.51) | KEAP1HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4372953-A | Tetrazole derivatives, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1983-02-08 | — | — | US | disclosed |
| EP-0035228-A1 | Tetrazole derivatives, process for the preparation thereof, and anti-ulcer composition containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-09-09 | — | — | EP | disclosed |
| US-4060630-A | Ethylenediamine derivatives useful in treating sickle cell anemia | RICHARDSON-MERRELL INC. (US) | 1977-11-29 | — | — | US | disclosed |