Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784684 | 0.79 | MAPT (0.48) | MAPTGAAKEAP1KDM4EHIF1A | |
| SCHEMBL27768522 | 0.73 | MAPT (0.49) | MAPTGAAKDM4EHIF1AHDAC3 | |
| SCHEMBL27768438 | 0.71 | MAPT (0.53) | MAPTGAAKDM4EHIF1A | |
| SCHEMBL27768409 | 0.70 | GAA (0.54) | MAPTGAASMN1; SMN2 | |
| SCHEMBL13229755 | 0.69 | S1PR5 (0.53) | MAPTGAAKDM4EHIF1AFFAR1 | |
| SCHEMBL13228878 | 0.69 | MAPT (0.49) | MAPTGAAKDM4EHDAC6 | |
| SCHEMBL27768482 | 0.68 | S1PR5 (0.51) | MAPTGAAFFAR1 | |
| SCHEMBL27790051 | 0.68 | S1PR5 (0.47) | MAPTGAAFFAR1 | |
| SCHEMBL7350860 | 0.67 | CPA3 (0.71) | MAPTCPA3MMP3KEAP1HDAC3 | |
| SCHEMBL12628272 | 0.66 | BRD4 (0.49) | MAPTGAAMAPK1PTGER1PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4374847-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1983-02-22 | — | — | US | disclosed |