SCHEMBL11201474

SCHEMBL11201474

CC(C)C(=O)NCCNCC(O)COc1cccc2[nH]ccc12

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 15/20 0.64
ADRB2 P07550 5/20 0.64
ADRB1 P08588 5/20 0.64
HTR1A P08908 3/20 0.64
CYP1A2 P05177 2/20 0.64
CYP3A4 P08684 2/20 0.64
LMNA P02545 2/20 0.64
KDM4E B2RXH2 1/20 0.64
USP2 O75604 1/20 0.64
CYP2D6 P10635 1/20 0.64
THRB P10828 1/20 0.64
CYP2C9 P11712 1/20 0.64
TSHR P16473 1/20 0.64
TP53 P04637 1/20 0.64
GLA P06280 1/20 0.64
ALOX15 P16050 1/20 0.64
NFKB1 P19838 1/20 0.64
DRD4 P21917 1/20 0.64
HTR1B P28222 1/20 0.64
HTR2C P28335 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11195231 0.84 ADRB3 (0.48) ADRB3ADRB2ADRB1HTR1ACYP1A2
SCHEMBL6056296 0.83 HTR1A (0.71) ADRB3ADRB2ADRB1HTR1ACYP1A2
SCHEMBL4845543 0.82 HTR1A (0.76) ADRB3ADRB2ADRB1HTR1ACYP1A2
Bicarbonate SCHEMBL11121026 0.81 ADRB3 (0.59) ADRB3ADRB2ADRB1HTR1ACYP1A2
SCHEMBL22279163 0.80 ADRB1 (0.65) ADRB3ADRB2ADRB1HTR1ACYP1A2
SCHEMBL10504370 0.79 ADRB3 (0.51) ADRB3ADRB2ADRB1HTR1ACYP1A2
SCHEMBL11571350 0.79 ADRB2 (0.57) ADRB3ADRB2ADRB1CYP1A2LMNA
Pindolol SCHEMBL5220 0.79 HTR1A (1.00) ADRB3ADRB2ADRB1HTR1ACYP1A2
Pindolol SCHEMBL5219 0.79 HTR1A (1.00) ADRB3ADRB2ADRB1HTR1ACYP1A2
Pindolol SCHEMBL29379249 0.79 HTR1A (1.00) ADRB3ADRB2ADRB1HTR1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 US disclosed
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 US disclosed
US-4034106-A HEART DISEASE AND HYPERTENSION PROPHYLAXIS, B-ANDROGENIC BLOCKING IMPERIAL CHEMICAL INDUSTRIES LIMITED (EN) 1977-07-05 US disclosed