Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.54 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 6/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384813 | 0.76 | NOTUM (1.00) | NOTUMMAP2K1 | |
| SCHEMBL9536559 | 0.75 | GSTP1 (0.47) | NOTUMGSTP1CYP11B1CYP11B2PTGER3 | |
| SCHEMBL11204644 | 0.74 | MEN1 (0.58) | NOTUMMAP2K1 | |
| SCHEMBL23207309 | 0.74 | CA9 (0.62) | NOTUMGSTP1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8535240 | 0.72 | NOTUM (0.68) | NOTUMMAP2K1MMP1MMP12PIM1 | |
| SCHEMBL20719712 | 0.72 | GABRA1 (0.54) | PTGER3 | |
| SCHEMBL20719071 | 0.72 | PTGER3 (0.49) | PTGER3PIM1 | |
| SCHEMBL9701825 | 0.72 | NOTUM (0.62) | NOTUMMAP2K1 | |
| SCHEMBL7368040 | 0.72 | NOTUM (0.62) | NOTUMMAP2K1MMP1MMP12 | |
| SCHEMBL25078457 | 0.72 | NOTUM (0.62) | NOTUMMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |