Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320524 | 0.76 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL6629780 | 0.73 | NPC1 (0.56) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL5616625 | 0.72 | KMT2A (0.51) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL11796988 | 0.72 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1GAAHTTKMT2A | |
| SCHEMBL28007813 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL5572448 | 0.71 | RAB9A (0.73) | SMN1; SMN2ALDH1A1HTTNPC1KMT2A | |
| Phenyl Phenylcarbamate SCHEMBL272994 | 0.71 | ALDH1A1 (0.76) | SMN1; SMN2ALDH1A1GAAHTTKMT2A | |
| SCHEMBL11250840 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL19661051 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1GAAHTTNPC1 | |
| SCHEMBL59717 | 0.70 | RAB9A (0.55) | SMN1; SMN2ALDH1A1GAAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1616386-A | Intermediate for preparing isothiazole derivatives | PFIZER PROD INC (US) | 2005-05-18 | — | — | CN | disclosed |
| CN-1172918-C | Isothiazole derivatives as anticancer agents | �Ʒ� | 2004-10-27 | — | — | CN | disclosed |
| CN-1303380-A | Isothiazole derivatives as anticancer agents | PFIZER PROD INC (US) | 2001-07-11 | — | — | CN | disclosed |
| EP-0073973-A1 | Thiazolyl and isothiazolyl-carboxylic-acid anilides, process for their preparation and their utilization as fungicides | BASF Aktiengesellschaft (DE) | 1983-03-16 | — | — | EP | disclosed |
| EP-0073973-A1 | Thiazolyl and isothiazolyl-carboxylic-acid anilides, process for their preparation and their utilization as fungicides | BASF Aktiengesellschaft (DE) | 1983-03-16 | — | — | EP | disclosed |
| EP-0073973-A1 | Thiazolyl and isothiazolyl-carboxylic-acid anilides, process for their preparation and their utilization as fungicides | BASF Aktiengesellschaft (DE) | 1983-03-16 | — | — | EP | disclosed |