Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CNR1 | P21554 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6419975 | 0.81 | ALDH1A1 (0.59) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL989796 | 0.80 | TAAR1 (0.55) | SMN1; SMN2MEN1KMT2ACNR1MAPT | |
| SCHEMBL28980137 | 0.78 | MAPT (0.53) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL10395208 | 0.77 | SIGMAR1 (0.73) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL6237452 | 0.75 | L3MBTL1 (0.59) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10812127 | 0.75 | HTR2A (0.60) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL5010087 | 0.74 | CNR1 (0.53) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL3907319 | 0.74 | L3MBTL1 (0.70) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 | |
| SCHEMBL9523328 | 0.74 | SIGMAR1 (0.70) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL22834239 | 0.73 | CNR1 (1.00) | SMN1; SMN2MEN1KMT2ACNR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |