Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIMP3 | P35625 | 6/20 | 0.56 |
| ▸ | CD40 | P25942 | 3/20 | 0.52 |
| ▸ | CD40LG | P29965 | 3/20 | 0.52 |
| ▸ | FGF1 | P05230 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPSE | Q9Y251 | 6/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.45 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.45 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | CBX7 | O95931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908939 | 0.93 | CD40 (0.52) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11335520 | 0.88 | TIMP3 (0.63) | TIMP3MEN1USP2RECQLKMT2A | |
| SCHEMBL11355263 | 0.86 | TIMP3 (0.54) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11433094 | 0.86 | TTR (0.46) | TIMP3CD40CD40LGMEN1USP2 | |
| SCHEMBL11341705 | 0.85 | FGF1 (0.56) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11344939 | 0.84 | HPSE (0.49) | TIMP3CD40CD40LGMEN1USP2 | |
| SCHEMBL11340875 | 0.83 | TIMP3 (0.47) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11342760 | 0.83 | TIMP3 (0.56) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11342795 | 0.83 | CD40 (0.58) | TIMP3CD40CD40LGFGF1MEN1 | |
| SCHEMBL11761700 | 0.83 | TIMP3 (0.68) | TIMP3CD40CD40LGFGF1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013784-B1 | C-SUBSTITUTED NAPHTHALENEMONOSULFONIC UREIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN CYANAMID COMPANY (US) | 1983-02-23 | — | — | EP | disclosed |
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |