Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7362493 | 0.85 | RAB9A (0.50) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL9641365 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL25528963 | 0.78 | LMNA (0.58) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL7364359 | 0.77 | TOP2A (0.51) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL1120518 | 0.77 | GAA (0.53) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL966665 | 0.76 | NPC1 (0.59) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL30058651 | 0.76 | NPC1 (0.59) | ALDH1A1MAPTNPC1RAB9APKM | |
| SCHEMBL1120545 | 0.75 | GAA (0.57) | ALDH1A1MAPTNPC1RAB9ATSHR | |
| SCHEMBL714353 | 0.74 | THRB (0.63) | ALDH1A1MAPTNPC1RAB9AKDM4E | |
| SCHEMBL1120688 | 0.74 | MAPT (0.59) | ALDH1A1MAPTNPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280968-A2 | PYRIDO [3, 4-B]INDOLES AND METHODS OF USE | Medivation Technologies, Inc. (US) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009120717-A2 | PYRIDO [3, 4-B] INDOLES AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-10-01 | — | — | WO | disclosed |