Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL27940174 | 0.90 | KDM4E (0.63) | KDM4EALDH1A1MAPTRXFP1HTR2A | |
| SCHEMBL736956 | 0.85 | GPR84 (0.64) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL434877 | 0.85 | GPR84 (0.64) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL8291070 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1MAPTRXFP1HTR2A | |
| SCHEMBL3548958 | 0.79 | MAPT (0.58) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL29162323 | 0.79 | MAPT (0.58) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL27690773 | 0.79 | HTR2A (0.59) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL5730817 | 0.79 | MAPT (0.58) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL27795869 | 0.79 | MAPT (0.58) | KDM4EALDH1A1MAPTHTR2AMEN1 | |
| SCHEMBL27911671 | 0.78 | GPR84 (0.75) | KDM4EALDH1A1MAPTHTR2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114014859-A | Triazole indolol compound and synthesis method thereof | 绍兴文理学院 | 2022-02-08 | — | — | CN | claimed |
| US-7741343-B2 | 6H-oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2010-06-22 | — | — | US | claimed |
| EP-1383774-B1 | DIHYDROIMIDAZO¬4,5-E INDOLE AND 7H-PYRROLO¬3,2-F QUINOXALINE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2008-05-07 | — | — | EP | claimed |
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | SCHIEMANN KAI | 2008-02-28 | — | — | US | claimed |
| US-7291633-B2 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2007-11-06 | — | — | US | claimed |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | MERCK PATENT GMBH (DE) | 2005-05-12 | — | — | US | claimed |
| EP-1392699-B1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2005-03-16 | — | — | EP | claimed |
| EP-1392699-A1 | 6H-OXAZOLO 4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GmbH (DE) | 2004-03-03 | — | — | EP | claimed |
| WO-2002088139-A1 | 6H-OXAZOLO[4,5-E]INDOLE DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND/OR SEROTONERGIC LIGANDS | MERCK PATENT GMBH (DE) | 2002-11-07 | — | — | WO | claimed |
| CN-114014859-A | Triazole indolol compound and synthesis method thereof | 绍兴文理学院 | 2022-02-08 | — | — | CN | disclosed |
| CN-110437236-B | Indole-1, 2-and 1, 4-benzodiazepine compound and synthetic method thereof | 青岛农业大学 | 2020-08-18 | — | — | CN | disclosed |
| CN-110437236-A | A kind of indoles -1,2- and 1,4- benzodiazepine compounds and its synthetic method | UNIV QINGDAO AGRICULTURAL | 2019-11-12 | — | — | CN | disclosed |
| US-20190270778-A1 | Cyclic Peptides As C5a Receptor Antagonists | PFIZER INC. (US) | 2019-09-05 | — | — | US | disclosed |
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-0373110-A2 | Pressure-sensitive or heat-sensitive recording material | CIBA-GEIGY AG (CH) | 1990-06-13 | — | — | EP | disclosed |
| US-4876357-A | FOR PRESSURE AND HEAT SENSITIVE ELEMENTS | CIBA-GEIGY CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |
| EP-0266310-A1 | Chromogenic phthalides and azaphthalides | CIBA-GEIGY AG (CH) | 1988-05-04 | — | — | EP | disclosed |
| EP-0228825-A1 | 6,7,8,9-Tetrahydro-10-methylpyrido [1,2-a]indol-9-amines and derivatives thereof | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-07-15 | — | — | EP | disclosed |
| US-4665183-A | Process for preparing 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof useful for the treatment of cognitive impairments | AMERICAN HOME PRODUCTS CORP. (US) | 1987-05-12 | — | — | US | disclosed |
| US-4624954-A | 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments | AMERICAN HOME PRODUCTS CORPORATION (US) | 1986-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051394-A1 | 6H-Oxazolo[4,5 e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | KDM4E 2577/4885ALDH1A1 2637/4885MAPT 449/4885 |
| US-20050101649-A1 | 6H-oxazolo[4,5-e]indole derivatives as nicotinic acetylcholine receptor ligands and/or serotonergic ligands | CHRM1, CHRNA5, CHRNA4 | KDM4E 2585/4885ALDH1A1 3084/4885MAPT 391/4885 |
| US-20190270778-A1 | Cyclic Peptides As C5a Receptor Antagonists | C3AR1, C5AR1, C5AR2 | KDM4E 4412/4885ALDH1A1 3891/4885MAPT 4259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.