Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11442611 | 1.00 | ADRA1A (0.47) | ADRA1APRMT1MAPK1PLA2G10MMP8 | |
| SCHEMBL11210981 | 0.99 | ADRA1A (0.45) | ADRA1APRMT1MAPK1PLA2G10MMP8 | |
| SCHEMBL11209304 | 0.89 | MMP8 (0.39) | ADRA1AMAPK1MMP8CPB2MME | |
| SCHEMBL9069306 | 0.89 | ECE1 (0.43) | MMEKISS1R | |
| SCHEMBL10916522 | 0.86 | CYP1A2 (0.37) | ADRA1APLA2G10MMEKISS1REPHX2 | |
| SCHEMBL11268857 | 0.81 | KISS1R (0.37) | MAPK1MMP8CPB2MMEKISS1R | |
| SCHEMBL11210460 | 0.80 | ADRA1A (0.49) | ADRA1APRMT1MAPK1PLA2G10MMP8 | |
| SCHEMBL11268863 | 0.80 | CAPN1 (0.36) | MAPK1MMP8CPB2MMEKISS1R | |
| SCHEMBL7274410 | 0.79 | CYP1A2 (0.58) | MME | |
| SCHEMBL7273819 | 0.79 | CYP1A2 (0.58) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021766-B1 | INHIBITORS OF MAMMALIAN COLLAGENASE | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |
| US-4297275-A | Inhibitors of mammalian collagenase | E. R. SQUIBB & SONS, INC. (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0021766-A2 | Inhibitors of mammalian collagenase | E.R. Squibb & Sons, Inc. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4235885-A | Inhibitors of mammalian collagenase | E. R. SQUIBB & SONS, INC. (US) | 1980-11-25 | — | — | US | disclosed |