Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | PNMT | P11086 | 10/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11337914 | 0.89 | PNMT (0.39) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL9573119 | 0.76 | ADRA2A (0.39) | HTR2CPNMTADRA2AADRA2BADRA2C | |
| SCHEMBL30908737 | 0.68 | NOTUM (0.46) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL18524345 | 0.65 | — | — | |
| SCHEMBL9573156 | 0.64 | HTR2A (0.38) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL7321373 | 0.64 | HTR2A (0.48) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL9510557 | 0.64 | HTR2A (0.35) | HTR2AHTR2CHTR2BPNMTADRA2A | |
| SCHEMBL9573416 | 0.63 | CHRNB2 (0.33) | — | |
| SCHEMBL184440 | 0.63 | ALK (0.30) | — | |
| SCHEMBL17372829 | 0.60 | PNMT (0.31) | PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040990-B1 | ANTIALLERGIC IMIDODISULFAMIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| US-4317826-A | TREATING ASTHMA | SMITHKLINE CORPORATION (US) | 1982-03-02 | — | — | US | disclosed |
| EP-0040990-A1 | Antiallergic imidodisulfamides, their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-12-02 | — | — | EP | disclosed |