Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11206711 | 0.85 | HDAC1 (0.47) | HDAC1HDAC8TAAR1HTR2BOPRM1 | |
| SCHEMBL11210108 | 0.85 | HDAC1 (0.47) | HDAC1HDAC8TAAR1HTR2BOPRM1 | |
| SCHEMBL11203221 | 0.85 | THRB (0.43) | HDAC1HDAC8FFAR4TAAR1HTR2B | |
| SCHEMBL11209543 | 0.82 | MAPT (0.45) | HDAC1HDAC8MAPT | |
| SCHEMBL11205622 | 0.81 | NAAA (0.45) | FFAR4TAAR1GRM2GRM3HTR2B | |
| SCHEMBL11200671 | 0.81 | HDAC1 (0.49) | HDAC1HDAC8FFAR4S1PR1GRK5 | |
| SCHEMBL7431979 | 0.79 | HDAC1 (0.41) | HDAC1HDAC8HTR2BOPRM1CHRM3 | |
| SCHEMBL7428692 | 0.78 | ALDH1A1 (0.41) | HDAC1HDAC8FFAR4MAOBMEN1 | |
| SCHEMBL11205844 | 0.78 | MAPT (0.45) | HDAC1HDAC8FFAR4TAAR1MAOB | |
| SCHEMBL11207729 | 0.78 | MAPT (0.47) | HDAC1HDAC8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025192-B1 | SUBSTITUTED OXIRANE CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1983-05-11 | — | — | EP | claimed |
| EP-0025192-A2 | Substituted oxirane carboxylic acids, process for their preparation, their use and medicines containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1981-03-18 | — | — | EP | claimed |