Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 13/20 | 0.37 |
| ▸ | BCHE | P06276 | 8/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857640 | 0.78 | PRMT6 (0.51) | PRMT6ACHEBCHEHRH2 | |
| SCHEMBL11360362 | 0.78 | PRMT6 (0.55) | PRMT6ACHEBCHEHRH2 | |
| SCHEMBL11463439 | 0.77 | PRMT6 (0.50) | PRMT6ACHEBCHECYP1A2CYP3A4 | |
| SCHEMBL10846891 | 0.77 | PRMT6 (0.50) | PRMT6ACHEBCHECYP1A2CYP3A4 | |
| SCHEMBL10741444 | 0.76 | PRMT6 (0.61) | PRMT6ACHEBCHEHRH2 | |
| SCHEMBL10848949 | 0.75 | PRMT6 (0.49) | PRMT6ACHEBCHE | |
| Hydrochloric Acid SCHEMBL11475500 | 0.75 | PRMT6 (0.49) | PRMT6ACHEBCHECYP1A2CYP3A4 | |
| SCHEMBL11371642 | 0.74 | PRMT6 (0.62) | PRMT6ACHEBCHEHRH2 | |
| SCHEMBL11361537 | 0.73 | PRMT6 (0.66) | PRMT6ACHEBCHECYP1A2CYP3A4 | |
| SCHEMBL11211136 | 0.73 | ACHE (0.57) | ACHEBCHECYP2C19HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002930-B1 | AMINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1983-12-14 | — | — | EP | disclosed |
| US-4304780-A | Aminoalkylthiophene derivatives as histamine H2 -antagonists | GLAXO GROUP LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |
| US-4279911-A | ANTIHISTAMINES | GLAXO GROUP LIMITED (GB) | 1981-07-21 | — | — | US | disclosed |
| US-4233302-A | ANTIHISTAMINES, ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1980-11-11 | — | — | US | disclosed |
| EP-0002930-A1 | Amine derivatives, their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1979-07-11 | — | — | EP | disclosed |