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Sugi Predict / Compounds / Cloprednol

Cloprednol

Cloprednol

SCHEMBL11209368

C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2C(O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 7/20 1.00
▸ NR3C1 P04150 7/20 1.00
▸ NR1I2 O75469 2/20 1.00
▸ MLNR O43193 1/20 1.00
▸ ADORA3 P0DMS8 1/20 1.00
▸ HTR2C P28335 1/20 1.00
▸ HIF1A Q16665 8/20 0.61
▸ HSD17B10 Q99714 8/20 0.61
▸ CYP3A4 P08684 5/20 0.61
▸ CYP2C19 P33261 3/20 0.61
▸ ABCB11 O95342 2/20 0.61
▸ SERPINA6 P08185 2/20 0.61
▸ NR3C2 P08235 2/20 0.61
▸ AR P10275 2/20 0.61
▸ TNF P01375 1/20 0.61
▸ IL6 P05231 1/20 0.61
▸ GLUL P15104 1/20 0.61
▸ ADAM17 P78536 1/20 0.61
▸ GPBAR1 Q8TDU6 1/20 0.61
▸ ALDH1A1 P00352 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cloprednol SCHEMBL19327143 1.00 PGR (1.00) PGRNR3C1NR1I2MLNRADORA3
Cloprednol SCHEMBL4886 1.00 PGR (1.00) PGRNR3C1NR1I2MLNRADORA3
Cloprednol SCHEMBL25308351 0.97 PGR (0.95) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11853459 0.90 PGR (0.81) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11853469 0.90 PGR (0.81) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11860993 0.89 PGR (0.80) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11860982 0.89 PGR (0.80) PGRNR3C1NR1I2MLNRADORA3
Cloprednol SCHEMBL3999177 0.84 NR3C1 (0.71) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11202047 0.83 PGR (0.70) PGRNR3C1NR1I2MLNRADORA3
SCHEMBL11202042 0.83 PGR (0.70) PGRNR3C1NR1I2MLNRADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4051241-A ANTIALLERGIC AGENTS, ANTIRHEUMATIC AGENTS, DERMATOLOGIC DRUGS ION SYNTEX (U.S.A.) INC. (US) 1977-09-27 — — US claimed
US-11913031-B2 Method to reproduce circadian rhythms on a microfluidic chip YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2024-02-27 — — US disclosed
US-20200318077-A1 METHOD TO REPRODUCE CIRCADIAN RHYTHMS ON A MICROFLUIDIC CHIP YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2020-10-08 — — US disclosed
EP-0042451-B1 PROCESS FOR THE PREPARATION OF 11-BETA-HYDROXY STEROIDS SCHERING AKTIENGESELLSCHAFT (DE) 1983-06-22 — — EP disclosed
US-4353985-A FERMENTATION WITH CURVULARIA SCHERING AKTIENGESELLSCHAFT (DE) 1982-10-12 — — US disclosed
US-4323564-A TOPICAL ANTIINFLAMMATORY TREATMENT SYNTEX (U.S.A.) INC. (US) 1982-04-06 — — US disclosed
EP-0042451-A1 Process for the preparation of 11-beta-hydroxy steroids SCHERING AKTIENGESELLSCHAFT (DE) 1981-12-30 — — EP disclosed
US-4296109-A ANTISHOCK, ANTIINFLAMMATORY SCHERING, AKTIENGESELLSCHAFT (DE) 1981-10-20 — — US disclosed
US-4051241-A ANTIALLERGIC AGENTS, ANTIRHEUMATIC AGENTS, DERMATOLOGIC DRUGS ION SYNTEX (U.S.A.) INC. (US) 1977-09-27 — — US disclosed
US-4051241-A ANTIALLERGIC AGENTS, ANTIRHEUMATIC AGENTS, DERMATOLOGIC DRUGS ION SYNTEX (U.S.A.) INC. (US) 1977-09-27 — — US disclosed
US-4051241-A ANTIALLERGIC AGENTS, ANTIRHEUMATIC AGENTS, DERMATOLOGIC DRUGS ION SYNTEX (U.S.A.) INC. (US) 1977-09-27 — — US disclosed
US-3984544-A Retinoic acid esters of steroids of the pregnane series, their use in the treatment of acne and pharmaceutical formulations useful therefor SCHERING CORPORATION (US) 1976-10-05 — — US disclosed