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Cloprednol

Cloprednol

SCHEMBL3999177

C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 7/20 0.71
▸ PGR P06401 4/20 0.71
▸ MLNR O43193 1/20 0.71
▸ NR1I2 O75469 1/20 0.71
▸ ADORA3 P0DMS8 1/20 0.71
▸ HTR2C P28335 1/20 0.71
▸ HSD17B10 Q99714 10/20 0.65
▸ SERPINA6 P08185 4/20 0.65
▸ CYP3A4 P08684 3/20 0.65
▸ SHBG P04278 2/20 0.65
▸ SMN1; SMN2 Q16637 2/20 0.65
▸ LMNA P02545 2/20 0.65
▸ ALDH1A1 P00352 2/20 0.65
▸ TSHR P16473 2/20 0.65
▸ CYP2D6 P10635 1/20 0.65
▸ PMP22 Q01453 1/20 0.65
▸ KCNA1 Q09470 1/20 0.65
▸ SLC47A1 Q96FL8 1/20 0.65
▸ HIF1A Q16665 5/20 0.59
▸ CYP2C19 P33261 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cortisone Acetate SCHEMBL7518922 0.95 NR3C1 (0.64) NR3C1PGRMLNRNR1I2ADORA3
Prednisolone SCHEMBL11710056 0.87 HSD17B10 (0.76) NR3C1PGRHSD17B10SERPINA6CYP3A4
Cloprednol SCHEMBL19327143 0.84 PGR (1.00) NR3C1PGRMLNRNR1I2ADORA3
Cloprednol SCHEMBL4886 0.84 PGR (1.00) NR3C1PGRMLNRNR1I2ADORA3
Cloprednol SCHEMBL11209368 0.84 PGR (1.00) NR3C1PGRMLNRNR1I2ADORA3
Prednisone SCHEMBL15516322 0.84 HSD17B10 (0.75) NR3C1PGRHSD17B10SERPINA6CYP3A4
Meprednisone SCHEMBL13723450 0.84 NR3C1 (0.68) NR3C1PGRMLNRNR1I2ADORA3
Cortisone SCHEMBL442505 0.84 HIF1A (0.85) NR3C1PGRHSD17B10SERPINA6CYP3A4
Methylprednisolone SCHEMBL8902882 0.83 HSD17B10 (0.73) NR3C1PGRNR1I2HSD17B10SERPINA6
Cloprednol SCHEMBL25308351 0.82 PGR (0.95) NR3C1PGRMLNRNR1I2ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009076454-A2 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM CALCIMEDICA, INC. (US) 2009-06-18 — — WO disclosed