Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.55 |
| ▸ | HTR5A | P47898 | 1/20 | 0.55 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD1 | P21728 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 5/20 | 0.53 |
| ▸ | DRD5 | P21918 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10019851 | 1.00 | HTR2A (0.57) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL30569666 | 1.00 | HTR2A (0.57) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL30569664 | 1.00 | HTR2A (0.57) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL23636196 | 0.87 | DRD5 (0.64) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL29378703 | 0.83 | KDM4E (0.66) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL2630572 | 0.83 | KDM4E (0.66) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL30583743 | 0.83 | KDM4E (0.66) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL10561615 | 0.79 | HTR2A (0.71) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL29629600 | 0.79 | HTR2A (0.71) | HTR2AHTR2CKDM4ENR2E1HTR5A | |
| SCHEMBL4278429 | 0.78 | KDM4E (0.56) | HTR2AHTR2CKDM4ENR2E1HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200113800-A1 | COSMETIC COMPOSITION | MANKE NICOLE (US) | 2020-04-16 | — | — | US | claimed |
| EP-1030663-B1 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | DESIGNED NUTRITIONAL PRODUCTS (US) | 2010-03-10 | — | — | EP | claimed |
| US-6613792-B1 | Treatment of premenstrual syndrome and menopause | DESIGNED NUTRITIONAL PRODUCTS, INC. | 2003-09-02 | — | — | US | claimed |
| EP-1030663-A4 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | DESIGNED NUTRITIONAL PRODUCTS (US) | 2002-06-26 | — | — | EP | claimed |
| WO-2001008637-A2 | TREATMENT OF PREMENSTRUAL SYNDROME AND MENOPAUSE | DESIGNED NUTRITIONAL PRODUCTS, INC. (US) | 2001-02-08 | — | — | WO | claimed |
| EP-1030663-A1 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | Designed Nutritional Products Inc. (US) | 2000-08-30 | — | — | EP | claimed |
| WO-1999017768-A1 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | DESIGNED NUTRITIONAL PRODUCTS, INC. (US) | 1999-04-15 | — | — | WO | claimed |
| US-20230285257-A1 | COSMETIC COMPOSITION | MANKE NICOLE (US) | 2023-09-14 | — | — | US | disclosed |
| US-20200113800-A1 | COSMETIC COMPOSITION | MANKE NICOLE (US) | 2020-04-16 | — | — | US | disclosed |
| US-9663462-B2 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles | BIORESPONSE, L.L.C. (US) | 2017-05-30 | — | — | US | disclosed |
| US-9353058-B2 | Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles | BIORESPONSE, L.L.C. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20160101083-A1 | ANTI-PARASITIC METHODS AND COMPOSITIONS UTILIZING DIINDOLYLMETHANE-RELATED INDOLES | BIORESPONSE, L.L.C. (US) | 2016-04-14 | — | — | US | disclosed |
| EP-1623985-B1 | ANALOGS OF INDOLE-3-CARBINOL METABOLITES AS CHEMOTHERAPEUTIC AND CHEMOPREVENTATIVE AGENTS | STANFORD RES INST INT (US) | 2016-02-17 | — | — | EP | disclosed |
| US-6800655-B2 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-10-05 | — | — | US | disclosed |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | JONG LING (US) | 2004-08-12 | — | — | US | disclosed |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | SRI INTERNATIONAL | 2004-03-04 | — | — | US | disclosed |
| US-6613792-B1 | Treatment of premenstrual syndrome and menopause | DESIGNED NUTRITIONAL PRODUCTS, INC. | 2003-09-02 | — | — | US | disclosed |
| EP-1030663-A4 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | DESIGNED NUTRITIONAL PRODUCTS (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1030663-A1 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | Designed Nutritional Products Inc. (US) | 2000-08-30 | — | — | EP | disclosed |
| WO-1999017768-A1 | TREATMENT OF FIBROMYALGIA AND RELATED DISORDERS | DESIGNED NUTRITIONAL PRODUCTS, INC. (US) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160101083-A1 | ANTI-PARASITIC METHODS AND COMPOSITIONS UTILIZING DIINDOLYLMETHANE-RELATED INDOLES | CASP3, IDO1, INMT | HTR2A 1177/4885HTR2C 1087/4885KDM4E 3429/4885 |
| US-20040043965-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | HTR2A 179/4885HTR2C 79/4885KDM4E 3192/4885 |
| US-20040157906-A1 | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents | IDO1, IDO2, TPH1 | HTR2A 179/4885HTR2C 79/4885KDM4E 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.