Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122 | 1.00 | ALOX15 (0.59) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL839 | 0.91 | MAPK1 (0.52) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL838 | 0.91 | MAPK1 (0.52) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL12857671 | 0.76 | MAOA (0.51) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL984 | 0.75 | HTR2A (0.54) | ALOX15MAPK1HTR2AHTR2CKDM4E | |
| SCHEMBL8792311 | 0.74 | ALOX15 (1.00) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL8792316 | 0.74 | ALOX15 (1.00) | ALOX15MAPK1MAPTHTR2AHTR2C | |
| SCHEMBL19159482 | 0.72 | HTR2A (0.47) | ALOX15MAPK1HTR2AHTR2CKDM4E | |
| SCHEMBL1004842 | 0.71 | MAPT (0.45) | ALOX15MAPK1MAPTKDM4EHSD17B10 | |
| SCHEMBL1004843 | 0.71 | MAPT (0.45) | ALOX15MAPK1MAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360800-A | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives | GLAXO GROUP LIMITED (GB) | 1994-11-01 | — | — | US | disclosed |
| US-4985422-A | TRICYCLIC, IMIDAZOLE SUBSTITUTED, ANTAGONIST OF HYDROXYTRYPTAMINE RECEPTORS, PSYCHOTIC DISORDERS, SCHIZOPHRENIA | GLAXO GROUP LIMITED (GB) | 1991-01-15 | — | — | US | disclosed |
| EP-0339959-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-11-02 | — | — | EP | disclosed |
| EP-0306323-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1989-03-08 | — | — | EP | disclosed |