Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CD44 | P16070 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.30 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11205980 | 0.83 | NPC1 (0.46) | PARP1RAF1ALOX5TDP1NPC1 | |
| SCHEMBL11209825 | 0.81 | PARP1 (0.38) | PARP1TAAR1ALOX5TDP1NPC1 | |
| SCHEMBL11207361 | 0.78 | ACP1 (0.42) | PARP1HRH2HRH1HRH4HRH3 | |
| SCHEMBL11210833 | 0.76 | TAAR1 (0.55) | RAF1TAAR1ALOX5TDP1NPC1 | |
| SCHEMBL11207941 | 0.74 | TAAR1 (0.39) | PARP1HRH2HRH1HRH4HRH3 | |
| SCHEMBL11205137 | 0.74 | PARP1 (0.36) | PARP1TAAR1ALOX5ACP1 | |
| SCHEMBL10790690 | 0.73 | TAAR1 (0.38) | PARP1HRH2HRH1HRH4HRH3 | |
| SCHEMBL11208607 | 0.72 | TUBB1 (0.41) | TAAR1ALOX5TDP1NPC1RAB9A | |
| SCHEMBL11204477 | 0.71 | MAPT (0.43) | TAAR1NPC1RAB9APOLBMAPT | |
| SCHEMBL11208575 | 0.71 | ALOX5 (0.45) | PARP1ALOX5TDP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0034474-B1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Farmos-Yhtyma Oy (FI) | 1983-01-26 | — | — | EP | disclosed |
| US-4333947-A | HYPOTENSIVE AGENTS, BACTERICIDES, FUNGICIDES | FARMOS-YHTYMA OY (FI) | 1982-06-08 | — | — | US | disclosed |
| EP-0034474-A1 | Substituted imidazoles, their preparation and pharmaceutical compositions containing the same | Farmos-Yhtyma Oy (FI) | 1981-08-26 | — | — | EP | disclosed |