Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020848 | 0.98 | RECQL (0.73) | RECQLKDM4EPOLBKMT2AMAPT | |
| Bromide SCHEMBL18496999 | 0.97 | RECQL (0.76) | RECQLKDM4EPOLBKMT2AMAPT | |
| SCHEMBL16663886 | 0.86 | RECQL (0.69) | RECQLKDM4EPOLBKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL11598725 | 0.86 | RECQL (0.65) | RECQLKDM4EPOLBKMT2AMAPT | |
| Bromide SCHEMBL5257266 | 0.83 | RECQL (1.00) | RECQLKDM4EPOLBKMT2AMAPT | |
| SCHEMBL8022993 | 0.83 | KDM4E (0.97) | RECQLKDM4EPOLBKMT2AMAPT | |
| Iodide SCHEMBL29210094 | 0.81 | KDM4E (0.94) | RECQLKDM4EPOLBKMT2AMAPT | |
| Bromide SCHEMBL8512189 | 0.81 | KDM4E (1.00) | RECQLKDM4EPOLBKMT2AMAPT | |
| SCHEMBL16663888 | 0.81 | RECQL (0.63) | RECQLKDM4EPOLBKMT2AMAPT | |
| Butyric Acid SCHEMBL1362446 | 0.80 | KDM4E (0.72) | RECQLKDM4EPOLBKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019299-B1 | PHOTOGRAPHIC SILVER HALIDE MATERIAL HAVING A COLOR FILTER LAYER OR AN ANTIHALATION DYE LAYER | CIBA-GEIGY AG (CH) | 1983-07-27 | — | — | EP | disclosed |
| US-4294916-A | METHINE DYES | CIBA-GEIGY AG (CH) | 1981-10-13 | — | — | US | disclosed |
| EP-0019299-A1 | Photographic silver halide material having a color filter layer or an antihalation dye layer | CIBA-GEIGY AG (CH) | 1980-11-26 | — | — | EP | disclosed |