Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8022993 | 0.98 | KDM4E (0.97) | KDM4EPOLBRECQLMAPTHTT | |
| Iodide SCHEMBL29210094 | 0.97 | KDM4E (0.94) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL16663887 | 0.90 | KDM4E (0.81) | KDM4EPOLBRECQLMAPTHTT | |
| Bromide SCHEMBL3915979 | 0.89 | KDM4E (0.80) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL15419914 | 0.88 | KDM4E (0.79) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL1105809 | 0.87 | KDM4E (0.77) | KDM4EPOLBRECQLMAPTHTT | |
| Iodide SCHEMBL2057098 | 0.86 | KDM4E (0.75) | KDM4EPOLBRECQLMAPTHTT | |
| SCHEMBL8512187 | 0.85 | KDM4E (0.74) | KDM4EPOLBRECQLMAPTHTT | |
| Bromide SCHEMBL18496999 | 0.84 | RECQL (0.76) | KDM4EPOLBRECQLMAPTHTT | |
| Butyric Acid SCHEMBL1362446 | 0.84 | KDM4E (0.72) | KDM4EPOLBRECQLMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999041409-A1 | CHROMOGENIC SUBSTRATES FOR THE DETECTION OF $i(SALMONELLA) | PRAILL PRICE RICHARDSON LTD. (GB) | 1999-08-19 | — | — | WO | disclosed |
| US-4386146-A | IMPROVED WHITENESS | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1983-05-31 | — | — | US | disclosed |