Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | F3 | P13726 | 3/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11211974 | 1.00 | CYP2D6 (0.60) | CYP2D6CYP1A2F3HSD11B1CA12 | |
| SCHEMBL28739924 | 0.93 | F3 (0.65) | CYP2D6CYP1A2F3HSD11B1CA12 | |
| SCHEMBL11970891 | 0.92 | CYP1A2 (0.75) | CYP2D6CYP1A2F3CA12CA1 | |
| SCHEMBL11971159 | 0.92 | F3 (0.75) | CYP2D6CYP1A2F3HDAC1HDAC8 | |
| SCHEMBL11999782 | 0.92 | F3 (0.56) | CYP2D6CYP1A2F3HSD11B1CA12 | |
| SCHEMBL11970887 | 0.92 | CYP1A2 (0.75) | CYP2D6CYP1A2F3CA12CA1 | |
| SCHEMBL11971157 | 0.92 | F3 (0.75) | CYP2D6CYP1A2F3HDAC1HDAC8 | |
| SCHEMBL23046887 | 0.89 | GSK3B (0.65) | CYP2D6CYP1A2F3CA12CA1 | |
| SCHEMBL20586442 | 0.89 | GSK3B (0.65) | CYP2D6CYP1A2F3CA12CA1 | |
| SCHEMBL584591 | 0.87 | THRB (0.61) | CYP2D6CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008854-A1 | Pentadienone hydrazone, and its use as insecticidal agent | AMERICAN CYANAMID COMPANY (US) | 1980-03-19 | — | — | EP | claimed |
| US-4191768-A | Pentadienone hydrazones, method for preparing the same, and insecticidal use thereof | AMERICAN CYANAMID COMPANY (US) | 1980-03-04 | — | — | US | claimed |
| US-9174960-B2 | Compounds useful against kinetoplastideae parasites | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-11-03 | — | — | US | disclosed |
| US-9174960-B2 | Compounds useful against kinetoplastideae parasites | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-11-03 | — | — | US | disclosed |
| US-20120214996-A1 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-08-23 | — | — | US | disclosed |
| US-20120214996-A1 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-08-23 | — | — | US | disclosed |
| WO-2011033115-A2 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-03-24 | — | — | WO | disclosed |
| EP-0008854-B1 | PENTADIENONE HYDRAZONE, AND ITS USE AS INSECTICIDAL AGENT | AMERICAN CYANAMID COMPANY (US) | 1983-03-09 | — | — | EP | disclosed |
| EP-0008854-A1 | Pentadienone hydrazone, and its use as insecticidal agent | AMERICAN CYANAMID COMPANY (US) | 1980-03-19 | — | — | EP | disclosed |
| US-4191768-A | Pentadienone hydrazones, method for preparing the same, and insecticidal use thereof | AMERICAN CYANAMID COMPANY (US) | 1980-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214996-A1 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | TST, PDXK, TBCB | CYP2D6 863/4885CYP1A2 1796/4885F3 3037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.