Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PPOX | P50336 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11114839 | 0.89 | TDP1 (0.45) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL11266141 | 0.89 | TDP1 (0.45) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL11190333 | 0.89 | TDP1 (0.43) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL9120594 | 0.89 | MEN1 (0.52) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL10430085 | 0.88 | TDP1 (0.43) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL31118353 | 0.86 | TDP1 (0.60) | TDP1MAPTPOLBSIRT6MEN1 | |
| SCHEMBL10495360 | 0.86 | TDP1 (0.41) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL10877259 | 0.85 | ALDH1A1 (0.42) | TDP1MAPTPOLBMEN1KMT2A | |
| SCHEMBL8923180 | 0.85 | SCN9A (0.43) | TDP1MAPTMEN1KMT2ATTR | |
| SCHEMBL11272565 | 0.84 | TDP1 (0.41) | TDP1MAPTPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019388-B1 | PREPARATION OF TRIFLUOROMETHYL-SUBSTITUTED PHENOLS AND PHENATES AND THE PREPARATION, FROM THESE PHENOLS AND PHENATES, OF NITRO- AND TRIFLUOROMETHYL-SUBSTITUTED DIPHENYL ETHERS | ROHM AND HAAS COMPANY (US) | 1983-03-23 | — | — | EP | disclosed |