Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | SI | P14410 | 1/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185985 | 0.90 | ALDH1A1 (0.65) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL30839712 | 0.90 | ALDH1A1 (0.65) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL30839752 | 0.90 | ALDH1A1 (0.65) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL15989743 | 0.86 | TSHR (0.48) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL397076 | 0.85 | ALDH1A1 (0.54) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL464507 | 0.84 | AHR (0.64) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL29624840 | 0.84 | AHR (0.64) | TSHRCYP3A4TP53ALDH1A1TDP1 | |
| SCHEMBL14054914 | 0.81 | ITGB2 (0.59) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL14906969 | 0.78 | ALDH1A1 (0.56) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL22884435 | 0.77 | ALDH1A1 (0.50) | TSHRCYP3A4TP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086745-A1 | Process for the preparation of a very pure commercial form of 4,2',4'-trichloro-2-hydroxydiphenyl ether | CIBA-GEIGY AG (CH) | 1983-08-24 | — | — | EP | disclosed |