SCHEMBL22884435

SCHEMBL22884435

Nc1cc(Cl)ccc1-c1ccc(Br)cc1N

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
CYP3A4 P08684 4/20 0.50
TSHR P16473 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
ALOX15 P16050 2/20 0.50
TDP1 Q9NUW8 1/20 0.50
GPR35 Q9HC97 2/20 0.49
TP53 P04637 1/20 0.48
HPGD P15428 2/20 0.45
ALOX12 P18054 1/20 0.45
MAPK1 P28482 1/20 0.45
HSD17B10 Q99714 1/20 0.45
GAA P10253 2/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 3/20 0.39
LMNA P02545 1/20 0.39
HTT P42858 1/20 0.39
MGAM O43451 1/20 0.38
SI P14410 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15989743 0.90 TSHR (0.48) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL30839712 0.86 ALDH1A1 (0.65) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL30839752 0.86 ALDH1A1 (0.65) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL27185985 0.86 ALDH1A1 (0.65) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL2841295 0.86 GPR35 (0.59) ALDH1A1ALOX15GPR35MAPK1KMT2A
SCHEMBL23579060 0.83 GPR35 (0.42) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL17068906 0.78 TSHR (0.45) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL11214035 0.77 TSHR (0.58) ALDH1A1CYP3A4TSHRSMN1; SMN2ALOX15
SCHEMBL11728230 0.76 ALDH1A1 (0.59) ALDH1A1CYP3A4SMN1; SMN2ALOX15TDP1
SCHEMBL14906927 0.75 GPR35 (0.48) ALDH1A1CYP3A4TSHRALOX15TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3763720-B1 COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG CHEMICAL LTD (KR) 2023-11-22 EP disclosed
EP-3763720-A1 COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME LG CHEM, LTD. (KR) 2021-01-13 EP disclosed