Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.51 |
| ▸ | NOS1 | P29475 | 2/20 | 0.51 |
| ▸ | NOS2 | P35228 | 2/20 | 0.51 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.48 |
| ▸ | HTR3B | O95264 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 2/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574633 | 0.78 | HTR3E (0.53) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL7793312 | 0.78 | PNMT (0.47) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL3525971 | 0.76 | HTR3E (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8696375 | 0.75 | HTR3E (0.50) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL1374335 | 0.75 | — | — | |
| SCHEMBL2306420 | 0.74 | ALDH1A1 (0.46) | MEN1KMT2ACYP3A4CYP2C9TSHR | |
| SCHEMBL6380460 | 0.74 | NPC1 (0.46) | MEN1CYP2D6KMT2ACYP3A4THPO | |
| SCHEMBL30102029 | 0.74 | HTR3E (0.58) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL7870699 | 0.74 | HTR3E (0.58) | NOS3NOS1NOS2HTR3EHTR3B | |
| SCHEMBL3181009 | 0.74 | HTR3E (0.58) | NOS3NOS1NOS2HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0087709-A1 | N,N',N\"-triaryl-1,2,3-triaminopropane derivatives, process for their preparation and their use as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-07 | — | — | EP | claimed |
| EP-0087709-A1 | N,N',N\"-triaryl-1,2,3-triaminopropane derivatives, process for their preparation and their use as intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-09-07 | — | — | EP | disclosed |