Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649176 | 0.83 | NPC1 (0.43) | NPC1RAB9AKMT2AACHECYP1A2 | |
| SCHEMBL7649340 | 0.77 | MGLL (0.40) | NPC1RAB9AKMT2AACHEMEN1 | |
| SCHEMBL3525971 | 0.76 | HTR3E (0.50) | NPC1RAB9AKMT2AACHECYP1A2 | |
| SCHEMBL1547811 | 0.75 | — | — | |
| SCHEMBL2306420 | 0.74 | ALDH1A1 (0.46) | RAB9AKMT2AACHECYP3A4BLM | |
| SCHEMBL11214729 | 0.74 | NOS3 (0.51) | KMT2ACYP1A2CYP3A4CYP2D6THPO | |
| SCHEMBL30102203 | 0.74 | KMT2A (0.64) | NPC1RAB9AKMT2AACHECYP1A2 | |
| SCHEMBL28651876 | 0.74 | KMT2A (0.64) | NPC1RAB9AKMT2AACHECYP1A2 | |
| SCHEMBL28651874 | 0.74 | KMT2A (0.64) | NPC1RAB9AKMT2AACHECYP1A2 | |
| SCHEMBL4083264 | 0.74 | NPC1 (0.48) | NPC1RAB9AKMT2AACHECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113512029-A | Preparation and application of substituted pyrazole compound containing pyrimidinamine | 沈阳中化农药化工研发有限公司 | 2021-10-19 | — | — | CN | claimed |
| US-20160362427-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2016-12-15 | — | — | US | claimed |
| CN-113105334-B | Perovskite single crystal and preparation method and application thereof | 上海科技大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-113105334-B | Perovskite single crystal and preparation method and application thereof | 上海科技大学 | 2023-08-22 | — | — | CN | disclosed |
| CN-113512029-A | Preparation and application of substituted pyrazole compound containing pyrimidinamine | 沈阳中化农药化工研发有限公司 | 2021-10-19 | — | — | CN | disclosed |
| EP-0988309-B1 | C-4''-SUBSTITUTED MACROLIDE DERIVATIVES | PFIZER PROD INC (US) | 2005-11-23 | — | — | EP | disclosed |
| EP-1366026-B1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES | SUMITOMO CHEMICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-6420536-B1 | COMPOUNDS FOR USE IN THE TREATMENT AND PREVENTION OF BACTERIAL AND PROTOZOAN INFECTIONS | PFIZER INC | 2002-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160362427-A1 | BRIDGED BICYCLIC KALLIKREIN INHIBITORS | KLKB1, KLK1, KLK2 | NPC1 1491/4885RAB9A 2869/4885KMT2A 1323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.