Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 5/20 | 0.46 |
| ▸ | RARB | P10826 | 8/20 | 0.42 |
| ▸ | RARG | P13631 | 8/20 | 0.42 |
| ▸ | RARA | P10276 | 6/20 | 0.42 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3541162 | 0.89 | RXRA (0.58) | RXRARXRBRARBRARGRARA | |
| SCHEMBL9418950 | 0.85 | RXRA (0.51) | RXRARXRBRARBRARGRARA | |
| SCHEMBL11227826 | 0.81 | RXRA (0.43) | RXRARXRBRARBRARGRARA | |
| SCHEMBL7787543 | 0.80 | ABCB11 (0.46) | RXRARXRBRARBRARGRARA | |
| Bromide SCHEMBL9159462 | 0.79 | RXRA (0.42) | RXRARXRBRARBRARGRARA | |
| SCHEMBL9419052 | 0.76 | UGT2B7 (0.35) | RXRARXRBRARBRARGRARA | |
| SCHEMBL31085264 | 0.74 | RXRA (0.41) | RXRARXRBRARBRARGRARA | |
| SCHEMBL31003100 | 0.73 | RXRA (0.40) | RXRARXRBRARBRARGRARA | |
| SCHEMBL3175854 | 0.72 | RXRA (0.57) | RXRARXRBRARBRARGRARA | |
| Bromide SCHEMBL9860803 | 0.72 | RXRA (0.40) | RXRARXRBRARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326055-A | ANTITUMOR AGENTS, SKIN DISORDERS, RHEUMATIC DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1982-04-20 | — | — | US | disclosed |
| EP-0002742-B1 | STILBENE DERIVATIVES, THEIR PREPARATION AND MEDICINES CONTAINING THESE STILBENE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-04-14 | — | — | EP | disclosed |
| US-4193931-A | 7-(INDANYL OR NAPHTHYL)-3-METHYL-OCTA-2,4,6-TRIENE DERIVATIVES, ANTITUMOR | HOFFMANN-LA ROCHE INC. (US) | 1980-03-18 | — | — | US | disclosed |
| EP-0002742-A1 | Stilbene derivatives, their preparation and medicines containing these stilbene derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-07-11 | — | — | EP | disclosed |