Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT2B7 | P16662 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 4/20 | 0.32 |
| ▸ | RARB | P10826 | 4/20 | 0.32 |
| ▸ | RARG | P13631 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31085264 | 0.87 | RXRA (0.41) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL8732926 | 0.81 | RXRA (0.40) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL9419032 | 0.79 | RXRA (0.38) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL11215262 | 0.76 | RXRA (0.46) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL31003100 | 0.76 | RXRA (0.40) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL9145102 | 0.74 | NOX1 (0.36) | UGT2B7MEN1TSHRKMT2ANOX1 | |
| SCHEMBL9770517 | 0.73 | HPGD (0.41) | RXRARXRBMEN1TSHRKMT2A | |
| SCHEMBL3541162 | 0.73 | RXRA (0.58) | UGT2B7RXRARXRBRARARARB | |
| SCHEMBL9418988 | 0.72 | HTR2A (0.33) | UGT2B7RXRARXRB | |
| SCHEMBL9418950 | 0.70 | RXRA (0.51) | UGT2B7RXRARXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315071-B1 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | HOFFMANN LA ROCHE (CH) | 1994-07-20 | — | — | EP | disclosed |
| US-4992574-A | Skin disorders, antiallergens, antiinflammatory agent | HOFFMANN-LA ROCHE INC. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0315071-A2 | Benzocyclohepten derivatives, their preparation and utilisation for pharmaceutics | F. HOFFMANN-LA ROCHE AG (CH) | 1989-05-10 | — | — | EP | disclosed |