Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11217591 | 0.87 | THRB (0.51) | THRBFAAHPLA2G4BTSHRKMT2A | |
| SCHEMBL11218173 | 0.87 | TP53 (0.47) | SMN1; SMN2KDM4EALDH1A1TP53MAPT | |
| SCHEMBL15741849 | 0.81 | MTNR1A (0.57) | KMT2AMEN1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL27660549 | 0.80 | THRB (0.49) | THRBFAAHPLA2G4BTSHRKMT2A | |
| SCHEMBL11688473 | 0.77 | TSHR (0.44) | THRBPLA2G4BTSHRKMT2ASMPD1 | |
| SCHEMBL9487157 | 0.77 | TSHR (0.53) | THRBPLA2G4BTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL18883701 | 0.76 | TSHR (0.51) | THRBPLA2G4BTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL11218169 | 0.75 | LMNA (0.46) | NPC1RECQLTHRBTSHRKMT2A | |
| SCHEMBL11209971 | 0.75 | PLA2G4B (0.61) | THRBPLA2G4BPPARGPPARA | |
| SCHEMBL4990119 | 0.75 | KMT2A (0.65) | THRBFAAHPLA2G4BTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |