Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.67 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL15841614 | 0.89 | CA2 (0.65) | CA2CA1NFKB1GPR84TSHR | |
| Succinic Acid SCHEMBL27521722 | 0.89 | CA2 (0.65) | CA2CA1NFKB1GPR84TSHR | |
| SCHEMBL2235623 | 0.84 | ALDH1A1 (0.50) | CA2CA1TSHRTDP1CYP3A4 | |
| SCHEMBL27974131 | 0.82 | CA2 (0.56) | CA2CA1NFKB1GPR84TSHR | |
| Succinic Acid SCHEMBL27866447 | 0.81 | CA2 (0.79) | CA2CA1NFKB1GPR84TSHR | |
| Succinic Acid SCHEMBL10595739 | 0.78 | CA2 (0.59) | CA2CA1NFKB1GPR84TSHR | |
| Succinic Acid SCHEMBL27603375 | 0.77 | CA2 (0.72) | CA2CA1NFKB1GPR84TSHR | |
| SCHEMBL9623125 | 0.76 | LMNA (0.46) | CA2GPR84TSHRTDP1CYP3A4 | |
| Succinic Acid SCHEMBL9864674 | 0.75 | CA2 (0.51) | CA2GPR84TSHRTDP1CYP3A4 | |
| SCHEMBL11067290 | 0.74 | CA2 (0.69) | CA2CA1NFKB1GPR84TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342683-A | Azo dyes with carboxyl polyalkyleneoxy chain moiety | BAYER AKTIENGESELLSCHAFT (DE) | 1982-08-03 | — | — | US | disclosed |