Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.43 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11230105 | 0.88 | AVPR1A (0.48) | TPSAB1RAB9AAVPR1A | |
| SCHEMBL11223947 | 0.88 | AVPR1A (0.62) | TPSAB1AVPR1ACDK4CCND1ESR1 | |
| SCHEMBL11251234 | 0.88 | AVPR1A (0.49) | TPSAB1HTTAVPR1AALDH1A1ESR1 | |
| SCHEMBL11247565 | 0.88 | ALDH1A1 (0.51) | TPSAB1AVPR1AALDH1A1ESR1DRD2 | |
| SCHEMBL11221666 | 0.88 | KDM1A (0.54) | TPSAB1RAB9AAVPR1AALDH1A1ESR1 | |
| SCHEMBL11251330 | 0.87 | SMN1; SMN2 (0.56) | LMNARAB9AHTTALDH1A1USP2 | |
| SCHEMBL11223398 | 0.87 | ADAM17 (0.57) | TPSAB1RAB9AAVPR1AALDH1A1ESR1 | |
| SCHEMBL11221344 | 0.85 | TPSAB1 (0.48) | TPSAB1AVPR1AESR1DRD2DRD4 | |
| SCHEMBL11233891 | 0.85 | AVPR1A (0.47) | TPSAB1AVPR1AESR1DRD2DRD4 | |
| SCHEMBL11251657 | 0.84 | AVPR1A (0.50) | LMNAHTTAVPR1AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |