Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | AHR | P35869 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616428 | 0.83 | HRH3 (0.43) | IDO1LOXL2AHRHRH3HRH4 | |
| SCHEMBL28338445 | 0.80 | LOXL2 (0.69) | LOXL2AHRHRH3HRH4PCSK9 | |
| SCHEMBL401081 | 0.80 | LOXL2 (0.69) | LOXL2AHRHRH3HRH4PCSK9 | |
| SCHEMBL29403791 | 0.80 | LOXL2 (0.69) | LOXL2AHRHRH3HRH4PCSK9 | |
| SCHEMBL28335219 | 0.78 | LOXL2 (0.67) | LOXL2AHRHRH3PCSK9MTNR1A | |
| SCHEMBL28836433 | 0.76 | AHR (0.49) | LOXL2AHRPCSK9GUSB | |
| SCHEMBL10677541 | 0.75 | HRH3 (0.48) | IDO1LOXL2AHRHRH3HRH4 | |
| SCHEMBL6988526 | 0.75 | LOXL2 (0.53) | IDO1LOXL2AHRHRH3HRH4 | |
| Pyridine SCHEMBL27581580 | 0.74 | F2 (0.49) | IDO1LOXL2AHRF2 | |
| SCHEMBL6758056 | 0.74 | TAAR1 (0.51) | LOXL2AHRPCSK9GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4363912-A | 3-PYRIDYL-3-OR-4-ALKYL INDOLES | PFIZER INC. (US) | 1982-12-14 | — | — | US | disclosed |
| US-4101583-A | Alpha-methylthio-alpha-(2-aminophenyl) acetaldehyde diloweralkyl acetals | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-07-18 | — | — | US | disclosed |
| US-4080341-A | Carbazolenine and indole compounds | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-03-21 | — | — | US | disclosed |
| US-4067875-A | Certain N-phenyl or N-pyridyl aza sulfonium salts | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1978-01-10 | — | — | US | disclosed |
| US-3992392-A | Synthesis of indoles from anilines and intermediates therein | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1976-11-16 | — | — | US | disclosed |