Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.48 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12731847 | 0.85 | KDM4E (0.58) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL4234480 | 0.80 | LPAR3 (0.69) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL7504758 | 0.79 | ALOX5 (0.57) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL14876485 | 0.78 | ALOX5 (0.56) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL28639253 | 0.78 | ALOX5 (0.62) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL6207633 | 0.78 | ALOX5 (0.62) | ALOX5KDM4EALDH1A1L3MBTL1ACHE | |
| SCHEMBL30070354 | 0.78 | ALOX5 (0.62) | ALOX5KDM4EALDH1A1L3MBTL1ACHE | |
| SCHEMBL20439185 | 0.76 | ALOX5 (0.51) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL522710 | 0.76 | PIN1 (0.62) | ALOX5KDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL3586091 | 0.76 | POLB (0.62) | ALOX5KDM4EALDH1A1KMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1640367-B1 | ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF | SHANGHAI INST MATERIA MEDICA (CN) | 2011-02-09 | — | — | EP | disclosed |
| US-7683073-B2 | Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-03-23 | — | — | US | disclosed |
| US-20060135557-A1 | Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES | 2006-06-22 | — | — | US | disclosed |
| EP-1640367-A1 | ISOQUINOLINE -1,3,4-TRIONE, THE SYNTHETIC METHOD AND THE USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2006-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135557-A1 | Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof | APP, PSEN1, AIFM1 | ALOX5 552/4885KDM4E 4438/4885ALDH1A1 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.