Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11241085 | 0.84 | MAPT (0.36) | MEN1KMT2ACCNCCDK8MAPT | |
| SCHEMBL11234732 | 0.84 | PDE7A (0.38) | PDE7APDE4BPDE4DPDE7BMEN1 | |
| SCHEMBL11227511 | 0.75 | CCNC (0.41) | PDE7APDE4BPDE4DPDE7BMEN1 | |
| SCHEMBL11234631 | 0.74 | PDE7A (0.50) | PDE7APDE4BPDE4DPDE7BMEN1 | |
| SCHEMBL11226790 | 0.73 | NPC1 (0.47) | PDE4DALDH1A1RAB9AMAPK1L3MBTL1 | |
| SCHEMBL113118 | 0.72 | TXNRD1 (0.41) | PIN1GSRTXNRD1MAPTALDH1A1 | |
| SCHEMBL11237253 | 0.72 | HSD17B10 (0.37) | PDE7AMEN1KMT2APIN1MAPT | |
| SCHEMBL11237466 | 0.71 | CCNC (0.37) | MEN1KMT2ACCNCCDK8POLB | |
| SCHEMBL12454280 | 0.71 | EPHB3 (0.35) | PDE7AMEN1KMT2APIN1POLB | |
| SCHEMBL3791741 | 0.70 | DHFR (0.40) | PDE7APDE4BPDE4DPDE7BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |