Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11225899 | 0.84 | PDE7A (0.36) | PDE7ARAB9APDE4BPDE4DPDE7B | |
| SCHEMBL11240173 | 0.83 | ROCK2 (0.38) | CYP19A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL11237253 | 0.82 | HSD17B10 (0.37) | PDE7ARAB9ANPC1MEN1KMT2A | |
| SCHEMBL11234631 | 0.76 | PDE7A (0.50) | PDE7ARAB9ANPC1PDE4BPDE4D | |
| SCHEMBL11226790 | 0.75 | NPC1 (0.47) | CYP19A1RAB9ANPC1PDE4DALDH1A1 | |
| SCHEMBL12454280 | 0.73 | EPHB3 (0.35) | PDE7ACHUKMEN1KMT2AMAPT | |
| SCHEMBL3791741 | 0.72 | DHFR (0.40) | PDE7APDE4BPDE4DPDE7BCHUK | |
| SCHEMBL136263 | 0.71 | CTSB (0.53) | NPC1MAPTSMN1; SMN2ALDH1A1PIN1 | |
| SCHEMBL30574931 | 0.71 | CTSB (0.53) | NPC1MAPTSMN1; SMN2ALDH1A1PIN1 | |
| SCHEMBL171809 | 0.71 | HSD17B10 (0.52) | RAB9ANPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |