Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240092 | 0.83 | TSHR (0.39) | HSD17B10ALDH1A1TSHRTDP1CYP3A4 | |
| SCHEMBL11234732 | 0.82 | PDE7A (0.38) | HSD17B10PIN1MAPK1ALDH1A1HTT | |
| SCHEMBL18319705 | 0.77 | ERN1 (0.43) | ALDH1A1LMNATSHRTDP1MAPT | |
| SCHEMBL30574931 | 0.76 | CTSB (0.53) | HSD17B10PIN1MAPK1ALDH1A1LMNA | |
| SCHEMBL136263 | 0.76 | CTSB (0.53) | HSD17B10PIN1MAPK1ALDH1A1LMNA | |
| SCHEMBL11239468 | 0.75 | ABCG2 (0.41) | MAPK1ALDH1A1LMNAHTTTSHR | |
| SCHEMBL11234631 | 0.74 | PDE7A (0.50) | MAPK1ALDH1A1TSHRTDP1CYP3A4 | |
| SCHEMBL11226790 | 0.74 | NPC1 (0.47) | MAPK1ALDH1A1LMNACYP3A4NPC1 | |
| SCHEMBL16520976 | 0.73 | KMO (0.44) | ALDH1A1TSHRTDP1CYP3A4MAPT | |
| SCHEMBL4663094 | 0.72 | ALDH1A1 (0.46) | PIN1ALDH1A1TDP1PDE7ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |