Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.64 |
| ▸ | DRD1 | P21728 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226058 | 0.82 | SLC6A2 (0.71) | SLC6A2PTGS1KMT2AHIF1AMEN1 | |
| SCHEMBL7039636 | 0.81 | HIF1A (0.54) | SLC6A2PTGS1KMT2AHIF1AMEN1 | |
| Prenalterol SCHEMBL249753 | 0.80 | PTGS1 (1.00) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| Prenalterol SCHEMBL10816429 | 0.80 | PTGS1 (1.00) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| Prenalterol SCHEMBL10788435 | 0.80 | PTGS1 (1.00) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| SCHEMBL7042590 | 0.80 | ADRB2 (0.56) | SLC6A2PTGS1KMT2AHIF1AMEN1 | |
| SCHEMBL11284468 | 0.79 | PTGS1 (0.79) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| Prenalterol SCHEMBL11193769 | 0.79 | PTGS1 (0.97) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| Prenalterol SCHEMBL121857 | 0.79 | PTGS1 (0.97) | SLC6A2PTGS1KMT2AMEN1CYP2D6 | |
| Isoxsuprine SCHEMBL16491944 | 0.78 | HIF1A (1.00) | SLC6A2PTGS1KMT2AHIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244969-A | (P-HYDROXYPHENOXY)PROPANOLAMINE DERIVATIVES USEFUL AS B-RECEPTOR STIMULANTS | AKTIEBOLAGET HASSLE (SE) | 1981-01-13 | — | — | US | claimed |
| US-4336267-A | Heart active compounds and methods of use | AKTIEBOLAGET HASSLE (SE) | 1982-06-22 | — | — | US | disclosed |
| US-4244969-A | (P-HYDROXYPHENOXY)PROPANOLAMINE DERIVATIVES USEFUL AS B-RECEPTOR STIMULANTS | AKTIEBOLAGET HASSLE (SE) | 1981-01-13 | — | — | US | disclosed |