Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | THPO | P40225 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10866291 | 0.87 | ADRB2 (0.63) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| SCHEMBL11790301 | 0.86 | ADRB2 (0.56) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| SCHEMBL11284468 | 0.84 | PTGS1 (0.79) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| SCHEMBL10936166 | 0.84 | ADRB3 (0.62) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| SCHEMBL11791196 | 0.81 | ABCB1 (0.60) | ADRB2ADRB3ADRB1LMNATDP1 | |
| SCHEMBL11722838 | 0.81 | ADRB2 (0.50) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| SCHEMBL11722831 | 0.81 | ADRB2 (0.50) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| Prenalterol SCHEMBL249753 | 0.80 | PTGS1 (1.00) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| Prenalterol SCHEMBL10788435 | 0.80 | PTGS1 (1.00) | ADRB2ADRB3ADRB1PTGS1SLC6A2 | |
| Prenalterol SCHEMBL10816429 | 0.80 | PTGS1 (1.00) | ADRB2ADRB3ADRB1PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336267-A | Heart active compounds and methods of use | AKTIEBOLAGET HASSLE (SE) | 1982-06-22 | — | — | US | claimed |
| US-4336267-A | Heart active compounds and methods of use | AKTIEBOLAGET HASSLE (SE) | 1982-06-22 | — | — | US | disclosed |
| US-4244969-A | (P-HYDROXYPHENOXY)PROPANOLAMINE DERIVATIVES USEFUL AS B-RECEPTOR STIMULANTS | AKTIEBOLAGET HASSLE (SE) | 1981-01-13 | — | — | US | disclosed |