Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11224025 | 0.87 | KDM4E (0.42) | ALDH1A1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL11232223 | 0.85 | HTT (0.42) | ALDH1A1TDP1MAPTKMT2AMEN1 | |
| SCHEMBL11231834 | 0.84 | MAPT (0.38) | ALDH1A1TDP1MAPTCYP1A2CYP2C19 | |
| SCHEMBL11238965 | 0.83 | CYP1A2 (0.42) | ALDH1A1MAPTKMT2AMEN1CYP1A2 | |
| SCHEMBL11233166 | 0.83 | RAB9A (0.47) | ALDH1A1SMN1; SMN2TDP1MAPTKMT2A | |
| SCHEMBL11234835 | 0.83 | MPO (0.46) | MPOALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL11240020 | 0.81 | MAPT (0.42) | TDP1MAPTLMNACYP1A2CYP2C19 | |
| SCHEMBL11246747 | 0.80 | TDP1 (0.34) | ALDH1A1TDP1MAPTLMNAKDM4E | |
| SCHEMBL11237179 | 0.79 | DYRK1A (0.44) | ALDH1A1KMT2AMEN1GSK3BKDM4E | |
| SCHEMBL11238086 | 0.78 | TDP1 (0.47) | ALDH1A1TDP1MAPTLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317909-A | Preparation of 1,3-dihydro-5-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones | STERLING DRUG INC. (US) | 1982-03-02 | — | — | US | disclosed |
| US-4294836-A | 1,3-Dihydro-6-(pyridinyl)-2H-imidazo[4,5-b]pyridin-2-ones and -imidazo[4,5-b]-pyridine-2-thiones and their cardiotonic use | STERLING DRUG INC. (US) | 1981-10-13 | — | — | US | disclosed |